SML3278

AC-262536

≥95% (HPLC)

• Synonyme(s) : 154BG31, 4-(3-endo-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile, 4-[(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-naphthalenecarbonitrile, AC 262536, AC262536
• Formule empirique (notation de Hill) : C₁₈H₁₈N₂O
• Numéro CAS: 870888-46-3
• Poids moléculaire : 278.35
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD24386408
• Assay: ≥95% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C

Description

Biochem/physiol Actions

AC-262536 is a non-steroidal, tissue-selective androgen receptor (AR) modulator (SARM) that targets AR with high-affinity (pKi = 8.3 vs. 8.9/testosterone), potency (NIH-3T3/MDA-kb2 reporter assay pEC50 = 7.9/8.8 vs. 8.7/8.5/testosterone) and partial agonist activity (Emax = 67% and 72% of testosterone Emax, respectively by NIH-3T3 or MDA-kb2 assay) and high selectivity (no significant affinity for 47 other human nuclear receptors). AC-262536 antagonizes 10 nM DHT-induced LNCaP proliferation (by 47.2% at 100 nM) and prevents castration-induced LH upregulation in rats in vivo (EC50 = 2.8 mg/kg) with greatly reduced adverse effects than testosterone propionate (TP).

Non-steroidal, tissue-selective, potent and highly selective androgen receptor (AR) partial agonist in vitro and in vivo.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• WGK: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable