The axial Chloride in Ru265 dissociates quickly in aqueous solutions, converting to the aquated Ru265' form. Solutions should be prepared fresh.
SML2991
Ru265
≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor
Synonyme(s) :
Ru2(μ-N)(NH3)8Cl2]Cl3, trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex
Se connecter pour consulter les tarifs organisationnels et contractuels.
Sélectionner une taille de conditionnement
Changer de vue
| À vous/Référence | Disponibilité | Prix |
|---|
A propos de cet article
Formule empirique (notation de Hill) :
Cl5H24N9Ru2
Numéro CAS:
Poids moléculaire :
529.66
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aiderNom du produit
Ru265, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to dark beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl
Biochem/physiol Actions
Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.
Selective mitochondrial calcium uniporter (MCU) inhibitor that blocks mitochondrial Ca2+ uptake at a >10-fold greater potency as Ru360.
1 of 1
Cet article | |||
|---|---|---|---|
| form powder | form powder | form crystals | form powder |
| assay ≥95% (HPLC) | assay - | assay 95% | assay ≥99.9% trace metals basis |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. - |
| solubility H2O: 2 mg/mL, clear | solubility H2O: slightly soluble(lit.) | solubility - | solubility acetone: soluble ((lit.)), ethanol: soluble, water: soluble |
| color white to dark beige | color - | color - | color - |
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
-
Would the main stock of Ru265 prepared with H2O be safe for a month at -20C?
1 answer-
Helpful?
-
-
Is it possible to store in solution?
1 answer-
The solution stability of this product has not been evaluated. It is recommended to prepare fresh each time.
Helpful?
-