SML0848

LM22A-4

≥98% (HPLC)

• Synonyme(s) : N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
• Formule empirique (notation de Hill): C₁₅H₂₁N₃O₆
• Numéro CAS: 37988-18-4
• Poids moléculaire : 339.34
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• InChI: 1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
• Clé InChI: RGWJKANXFYJKHN-UHFFFAOYSA-N

Description

Application

LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.

Actions biochimiques/physiologiques

LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression.

LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC₅₀ of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable