SAB5701928

Anti-Phospho-MLKL-S454 antibody produced in rabbit

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: liquid
• Espèces réactives: human, mouse
• Concentration: 0.464 mg/mL
• Technique(s): western blot: 1:500-1:2000
• Numéro d'accès UniProt: Q8NB16
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer454)
• Informations sur le gène: human ... Phospho-MLKL-S454(197259)

Description

Description générale

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Immunogène

A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.

Forme physique

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable