SAB4502139

Anti-PDGFR α antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : α platelet-derived growth factor receptor precursor, CD140a, PDGF-R-α, PDGFR-α, kinase PDGFR-α
• Numéro MDL: MFCD01322518
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 122 kDa
• Espèces réactives: rat, human, mouse
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• Numéro d'accès NCBI: P16234
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PGFRA(5156)

Description

Description générale

Anti-PDGFR Anti-PDGFR α Antibody detects endogenous levels of total PDGFR α protein. Antibody detects endogenous levels of total PDGFR α protein.

Platelet-derived growth factor receptor α (PDGFRA), also known as cluster of differentiation 140a (CD140a), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the receptor tyrosine kinase gene family.

Immunogène

The antiserum was produced against synthesized peptide derived from human PDGFR alpha.

Immunogen Range: 731-780

Actions biochimiques/physiologiques

Platelet-derived growth factor receptor plays a vital role in the development and maturation of platelets. Platelet-derived growth factor receptor α (PDGFRA) acts as a potential target for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia. PDGFRA pathway might be involved in developmental process of thrombocytes. The encoded protein facilitates hepatic stellate cell (HSCs) proliferation and migration. Mutation in the gene has been observed in gastrointestinal stromal tumors (GISTs).

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable