R9281

Rotigotine hydrochloride

≥98% (HPLC)

• Synonyme(s) : (−)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol hydrochloride, (−)-N 0437, N 0923, Neupro, SPM 962
• Formule empirique (notation de Hill): C₁₉H₂₅NOS·HCl
• Numéro CAS: 125572-93-2
• Poids moléculaire : 351.93
• Numéro MDL: MFCD00906149
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824046
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: DMSO: >10 mg/mL
• Auteur: UCB Inc.
• Température de stockage: room temp
• Chaîne SMILES: Cl.CCCN(CCc1cccs1)[C@H]2CCc3c(O)cccc3C2
• InChI: 1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1
• Clé InChI: CEXBONHIOKGWNU-NTISSMGPSA-N

Description

Actions biochimiques/physiologiques

Rotigotine hydrochloride is a non-ergolinic D3/D2 and D1-dopamine agonist. It is appropriate for transdermal delivery through skin patches, that has the drug in a silicone-based adhesive matrix.

Rotigotine is a dopamine receptor agonist with preference for D₃ receptors over D₂ and D₁. As such, it is an effective anti-Parkinsonian agent. Racemic rotigotine is about 50 times as potent as quinpirole, the gold standard D₂ agonist.

Caractéristiques et avantages

This compound was developed by UCB Inc.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable