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Key Documents

PRS3941

Sigma-Aldrich

Anti-IRF7 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Interferon regulatory factor 7

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About This Item

Numéro MDL:
MFCD02096777
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human, rat, mouse

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Q92985

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... IRF7(3665)

Description générale

Interferon regulatory factor 7 (IRF7) protein, a multifunctional transcription factor, is a lymphoid-specific factor expressed in the cytoplasm in B cells, plasmacytoid dendritic cells (pDCs), and monocytes in the spleen, thymus, and peripheral blood lymphocytes. IRF7 gene is located on human chromosome 11p15.5.

Immunogène

a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 .

Application

Anti-IRF7 (ab1) antibody produced in rabbit has been used in immunoblotting.

Actions biochimiques/physiologiques

Interferon regulatory factor 7 (IRF7) protein plays a key role in regulating the type I interferon (IFN) alpha/beta (IFNα/β) responses, which are necessary to innate and adaptive immunity. Hence IRF7 is considered as the ‘master′ controller of IFN type I production. It plays a key role in priming. IRF7 can also form homodimers or heterodimers with interferon regulatory factor 5 (IRF5) to modulate target genes. It might regulate oncogenesis and apoptosis. IRF7 plays an important role in the pathogenesis of type I diabetes. It is connected to the latency of the Epstein–Barr virus (EBV).

Liaison

The action of this antibody can be blocked using blocking peptide SBP3941.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

S Ning et al.
Genes and immunity, 12(6), 399-414 (2011-04-15)
Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein-Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from
Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways
Gupta S, et al.
Asian Pacific Journal of Tropical Medicine (2018)
Marijana Sekulic-Jablanovic et al.
Frontiers in cellular neuroscience, 14, 566148-566148 (2020-11-17)
Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial for identifying potential pharmacological targets.

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