P4929

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt

double-stranded alternating copolymer

• Synonyme(s) : Poly(dI-dC) • Poly(dI-dC) sodium salt
• Numéro CAS: 118578-37-3
• UNSPSC Code: 41106305
• NACRES: NA.51
• MDL number: MFCD00131970
• Biological source: synthetic (organic)
• Form: powder
• Storage temp.: −20°C

Propriétés

• biological source: synthetic (organic)
• Quality Segment: 200
• form: powder
• storage temp.: −20°C

Description

Application

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in the electrophoretic mobility shift assay in p65 protein and neuro-2A protein lysate. It has also been used as a substrate in the protein arginine methyltransferase 1 (PRMT1) and DNA methyltransferase 1 (DNMT1) selectivity assay.

Poly(deoxyinosinic-deoxycytidylic) acid (Poly(dI-dC) • Poly(dI-dC)) is an alternating copolymer used as a DNA substrate for evaluation of DNA methytransfeases, such as DNA-methyltransferase 1 and as double-stranded DNA model for conformational studies of DNA structure dynamics and drug, small molecule, interactions.

Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has been used in a study that synthesized and characterized bis(2-(pyrimidin-2-γl)ethoxy)alkanes and their pharmacological activity. Poly(deoxyinosinic-deoxycytidylic) acid sodium salt has also been used in a study that investigated the growth of calcium carbonate films on LB/LbL matrices.

Biochem/physiol Actions

Poly(2′-deoxyinosinic-2′-deoxycytidylic acid), poly(dI-dC) is a synthetic DNA substrate. At high salt, Poly(dI-dC) exists in left handed helical conformation and reverts to right-handed form upon decreasing salt. It is used in electrophoretic mobility shift assay (EMSA).

Other Notes

Double-stranded alternating copolymer

One unit will yield an A₂₆₀ of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)