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P1152

Sigma-Aldrich

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide

greener alternative

Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

Synonyme(s) :

(L-Ala, L-Glu, L-Lys, L-Tyr)n ·HBr, COP-1

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About This Item

Numéro CAS:
28704-27-0
Numéro MDL:
MFCD00166401
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26

Forme

powder

Ratio alimentaire

Ala:Glu:Lys:Tyr (6:2:5:1)

Poids mol.

20,000-30,000

Score du produit alternatif plus écologique

old score: 56
new score: 39
Find out more about DOZN™ Scoring

Caractéristiques du produit alternatif plus écologique

Designing Safer Chemicals
Safer Solvents and Auxiliaries
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Couleur

white to off-white

Autre catégorie plus écologique

, Re-engineered

Température de stockage

−20°C

InChI

1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1

Clé InChI

YLOCGHYTXIINAI-XKUOMLDTSA-N

Description générale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Designing Safer Chemicals”, "Safer Solvents and Auxiliaries" and “Reduce Derivatives”. Click here to view its DOZN scorecard.

Actions biochimiques/physiologiques

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide is a polyamino acid reported to have a suppressive effect on allergic encephalomyelitis.
Reported to have suppressive effect on experimental allergic encephalomyelitis induced in laboratory animals.

Remarque sur l'analyse

Reported molecular weight based on viscosity.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

R Aharoni et al.
Immunology letters, 58(2), 79-87 (1997-07-01)
Graft-versus-host disease (GVHD), which occurs when donor T-cells recognize multiple minor host histocompatibility antigens as non-self, presents the major limitation to successful allogeneic bone-marrow transplantation. The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT
Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide.
D Teitelbaum et al.
European journal of immunology, 1(4), 242-248 (1971-08-01)
S D Lytton et al.
Parasite immunology, 15(8), 489-492 (1993-08-01)
The ability of Leishmania mexicana amazonensis to inhibit antigen specific T-cell proliferation against a non-parasite polypeptide antigen, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), was examined. Infection of mouse peritoneal macrophages by promastigotes blocked the proliferation of the T-cell line, TPB1. This effect was correlated
M Sela
Applied biochemistry and biotechnology, 83(1-3), 63-70 (2000-05-29)
The conformation of a peptide defines its antigenic specificity. In most cases, a free peptide is in a random form, whereas the same peptide within a protein has a defined conformation. Immunological cross-reactions between the two are rare. Nevertheless, there
E Zisman et al.
European journal of immunology, 24(10), 2497-2505 (1994-10-01)
Studies with the well-characterized, synthetic, random-multichain polypeptide poly(LTyr,LGlu)-poly(DLAla)-poly(LLys) (T,G)-A-L) led to the discovery of determinant-specific genetic control of the immune response, as well as to other immunological phenomena. Moreover, the tetrapeptide TyrTyrGluGlu built on the same backbone ("(T-T-G-G)-A--L") was found
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