P0037

PP242 hydrate

≥98% (HPLC), powder

• Synonyme(s) : 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol
• Formule empirique (notation de Hill): C₁₆H₁₆N₆O · xH₂O
• Numéro CAS: 1173019-76-5
• Poids moléculaire : 308.34 (anhydrous basis)
• Numéro MDL: MFCD12828866
• Code UNSPSC : 12352200
• ID de substance PubChem : 329819988
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14
• InChI: 1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2
• Clé InChI: FMDOLJSFPXFBIL-UHFFFAOYSA-N

Description

Application

PP242 hydrate has been used:

• as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
• as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
• as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection

Actions biochimiques/physiologiques

PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.

Caractéristiques et avantages

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable