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O8264

Sigma-Aldrich

Anti-Orai1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

CRACM1, Calcium release-activated calcium channel protein 1, TMEM142A, Transmembrane protein 142A

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~35 kDa (non-glycosylated)
antigen ~50 kDa (glycosylated)

Espèces réactives

human

Concentration

~1.0 mg/mL

Technique(s)

western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1

Numéro d'accès UniProt

Q96D31

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ORAI1(84876)
mouse ... Orai1(109305)

Catégories apparentées

Description générale

ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca2+ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.

Immunogène

synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.

Application

Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.

Actions biochimiques/physiologiques

ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca2+ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Anti-STIM1 (N-terminal) antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

S6072

Anti-STIM1 (N-terminal) antibody produced in rabbit

Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1
Renshan Sun
PLoS ONE (2016)
Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function
Jennifer H. Cox
PLoS ONE (2013)
Changbo Zheng et al.
Frontiers in pharmacology, 8, 222-222 (2017-05-11)
Cardiac hypertrophy is a major risk factor for heart failure, which are among the leading causes of human death. Gastrodin is a small molecule that has been used clinically to treat neurological and vascular diseases for many years without safety
Microdeletion of 12q24.31: Report of a Girl With Intellectual Disability, Stereotypies, Seizures and Facial Dysmorphisms
Orazio Palumbo
American Journal of Medical Genetics. Part A (2014)
Yukari Endo et al.
Human molecular genetics, 24(3), 637-648 (2014-09-18)
The store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel is activated by diminished luminal Ca(2+) levels in the endoplasmic reticulum and sarcoplasmic reticulum (SR), and constitutes one of the major Ca(2+) entry pathways in various tissues. Tubular aggregates (TAs) are abnormal structures
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