N3279
Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse
clone 25623, purified immunoglobulin, lyophilized powder
Synonyme(s) :
Anti-NGF-β
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About This Item
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Source biologique
mouse
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
25623, monoclonal
Forme
lyophilized powder
Espèces réactives
human, rat, mouse
Technique(s)
capture ELISA: 2-8 μg/mL (detection antibody at 0.1-0.4 μg/ml)
neutralization: 0.1-0.4 μg/mL
Impuretés
endotoxin, tested
Isotype
IgG1
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NGF(4803)
mouse ... Ngf(18049)
Immunogène
recombinant human NGF-β.
Actions biochimiques/physiologiques
Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.
Forme physique
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Notes préparatoires
Purified using Protein G.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Josemberg S Baptista et al.
PloS one, 15(1), e0228155-e0228155 (2020-01-28)
Intervertebral disc (IVD) degeneration is a remodeling process mediated by several growth factors and cytokines. This process has been extensively studied in vitro and with pathologic specimens obtained during surgery for scoliosis or back pain. However, the occurrence and temporal
Seong Hoon Seo et al.
The Journal of investigative dermatology, 140(11), 2199-2209 (2020-04-06)
Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor potential vanilloid (TRPV) 3, a member of the thermosensitive transient receptor potential channels, is activated by innocuous heat and is abundantly expressed in keratinocytes. The potential role of
Wolfgang Andreas Nockher et al.
The Journal of allergy and clinical immunology, 117(3), 583-589 (2006-03-09)
Understanding the complex pathophysiology of allergic diseases has been a main challenge of clinical and experimental research for many years. It is well known that the allergic inflammation triggers neuronal dysfunction and structural changes in the diseased tissues such as
Y Indo
Clinical genetics, 82(4), 341-350 (2012-08-14)
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder characterized by insensitivity to pain, anhidrosis (the inability to sweat) and mental retardation. Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and
Hrishikesh M Mehta et al.
Journal of neuroscience research, 90(12), 2259-2271 (2012-08-21)
Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its
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