Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

M9771

Sigma-Aldrich

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin

elastase substrate

Synonyme(s) :

MeOSuc-AAPV-AMC

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C31H41N5O9
Numéro CAS:
72252-90-5
Poids moléculaire :
627.69
Numéro MDL:
MFCD00077135
Code UNSPSC :
12352204
ID de substance PubChem :
24897367
Nomenclature NACRES :
NA.32

Pureté

≥98% (HPLC)

Forme

powder

Solubilité

chloroform: 50 mg/mL, clear, colorless

Température de stockage

−20°C

Chaîne SMILES 

COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C31H41N5O9/c1-16(2)27(30(42)34-20-9-10-21-17(3)14-26(39)45-23(21)15-20)35-29(41)22-8-7-13-36(22)31(43)19(5)33-28(40)18(4)32-24(37)11-12-25(38)44-6/h9-10,14-16,18-19,22,27H,7-8,11-13H2,1-6H3,(H,32,37)(H,33,40)(H,34,42)(H,35,41)

Clé InChI

CMEUDEVBFFPSEI-UHFFFAOYSA-N

Application

N-Methoxysuccinyl-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin has been used as a substrate in elastase assay using bone marrow lysates and pancreatic lysates.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrats

Fluorogenic substrate for the assay of human leukocyte and porcine pancreatic elastase.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jonas Hahn et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1401-1414 (2018-08-22)
Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)-associated aggregation and cytokine/chemokine-release/degradation by normal and NSP-deficient human and mouse granulocytes. Stimulated with solid or
Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases.
M J Castillo et al.
Analytical biochemistry, 99(1), 53-64 (1979-10-15)
Gerrit Wolters-Eisfeld et al.
Experimental & molecular medicine, 50(10), 1-13 (2018-10-12)
Cosmc is ubiquitously expressed and acts as a specific molecular chaperone assisting the folding and stability of core 1 synthase. Thus, it plays a crucial role in the biosynthesis of O-linked glycosylation of proteins. Here, we show that ablation of
Teresa I Ng et al.
Antimicrobial agents and chemotherapy, 62(1) (2017-11-01)
Glecaprevir (formerly ABT-493) is a novel hepatitis C virus (HCV) NS3/4A protease inhibitor (PI) with pangenotypic activity. It inhibited the enzymatic activity of purified NS3/4A proteases from HCV genotypes 1 to 6 in vitro (half-maximal [50%] inhibitory concentration = 3.5
Gisele Pena de Oliveira et al.
Nutrients, 11(4) (2019-04-25)
The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS). Glutamine (Gln) decreases lung inflammation in experimental ARDS, but its impact on the formation of extracellular traps (ETs) in the lung is unknown.
Afficher tous les articles scientifiques apparentés

Articles

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique