M4531

Meclofenamic acid sodium salt

• Synonyme(s) : 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt
• Formule linéaire : C₁₄H₁₀Cl₂NO₂Na
• Numéro CAS: 6385-02-0
• Poids moléculaire : 318.13
• Numéro CE : 228-983-3
• Numéro MDL: MFCD00077376
• Code UNSPSC : 12352106
• ID de substance PubChem : 24278553
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Pureté: ≥93% (HPLC)
• Forme: powder
• Solubilité: water: 50 mg/mL, clear, colorless to faintly brownish-yellow; water: 50 mg/mL, clear, colorless to faintly yellow; water: 50 mg/mL, clear, colorless to very faintly brown
• Chaîne SMILES: [Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
• InChI: 1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
• Clé InChI: CHGIZYUDGOIAFY-UHFFFAOYSA-N

Description

Description générale

Meclofenamic acid consists of two aryl moieties that are twisted in perpendicular orientation, it includes N-2,6-dichloro-3-methylphenyl group and N-2-benzoic acid group. Because of the low aqueous solubility of the compound, it is commercially available as sodium salt.

Application

Meclofenamic acid sodium salt has been used:

• in the inhibition of heat-induced denaturation of albumin
• as a pharmacological agent in the preparation of superfusion solution for electrophysiology studies
• to block the gap junctions

Actions biochimiques/physiologiques

Meclofenamic acid (MFA) is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug. It inhibits prostaglandin biosynthesis pathway and finds its application in the treatment of postoperative and traumatic inflammation and swelling. MFA functions in opening the potassium voltage-gated channel subfamily Q member 2/member 3 (KCNQ2/Q3).

Cyclooxygenase (IC₅₀ = 0.6 μM) and 5-lipoxygenase (IC₅₀ = 46.3 μM) inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)