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A propos de cet article
Formule empirique (notation de Hill) :
C18H25N2NaO4
Numéro CAS:
Poids moléculaire :
356.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
Service technique
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solid
Quality Level
color
white
solubility
H2O: soluble
SMILES string
[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccccc1
InChI
1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1
InChI key
UFMWGCINVOIJSO-UHFFFAOYSA-M
Gene Information
human ... CCK(885), CCKAR(886), CCKBR(887)
mouse ... CCK(12424)
rat ... CCK(25298)
Application
Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
Biochem/physiol Actions
Proglumide sodium salt is a non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype. It selectively blocks central nervous system effects. Proglumide sodium salt is orally active.
CCK antagonist; selectively blocks CNS effects.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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E S Corp et al.
Physiology & behavior, 61(6), 823-827 (1997-06-01)
Cholecystokinin (CCK) receptors are classified as two subtypes, designated CCK(A) and CCK(B), and both subtypes are found in brain and peripheral tissues of rats. CCK-8 has been shown to act peripherally to reduce meal size, and this satiating action can
J V Menani et al.
The American journal of physiology, 275(5 Pt 2), R1431-R1437 (1998-10-29)
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II
Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
V. C. Rubio
Physiology & Behavior (2008)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| M006-500MG | 04061832677194 |
| M006-100MG | 04061833992500 |