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I7908

Sigma-Aldrich

IL-2 human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture

Synonyme(s) :

IL-2, Interleukin-2, T-cell growth factor

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About This Item

Numéro MDL:
MFCD00165721
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.75

product name

Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in Pichia pastoris

Pureté

≥98% (SDS-PAGE and HPLC)

Forme

lyophilized powder

Poids mol.

predicted mol wt ~15 kDa

Conditionnement

pkg of 10KU

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P60568

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... IL2(3558)

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Catégories apparentées

Application

Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.

Actions biochimiques/physiologiques

Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.

Forme physique

Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.

Remarque sur l'analyse

The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Meera V Singh et al.
Journal of leukocyte biology, 109(4), 807-820 (2020-07-15)
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transient complexes with monocytes, especially in HIV infected individuals
Nader Bayda et al.
Cancers, 13(4) (2021-02-10)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We
TNFR1 and TNFR2 expression and induction on human Treg cells from type 1 diabetic subjects
Heinrich M, et al.
Antibodies, 4(1), 34-47 (2015)
Racha Bahri et al.
Cancers, 14(12) (2022-06-25)
The Epstein-Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL), a peripheral T lymphoma of poor prognosis in at least 90% of cases. The role of EBV in this pathology is unknown. Using next-generation sequencing, we sequenced the
The IL-2 receptor complex: its structure, function, and target genes
Minami, Y, et al.
Annual Review of Immunology, 11(1) (1993)
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