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H7654

Sigma-Aldrich

Hydroxyguanidine sulfate salt

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About This Item

Formule linéaire :
CH5N3O · 1/2H2SO4
Numéro CAS:
6345-29-5
Poids moléculaire :
124.11
Numéro CE :
228-749-0
Numéro MDL:
MFCD00042033
Code UNSPSC :
12352202
ID de substance PubChem :
329815245
Nomenclature NACRES :
NA.77

Source biologique

synthetic (organic)

Pureté

≥98% (TLC)

Forme

powder

Solubilité

water: 25 mg/mL, clear, colorless

Température de stockage

2-8°C

Chaîne SMILES 

NC(=N)NO.NC(=N)NO.OS(O)(=O)=O

InChI

1S/2CH5N3O.H2O4S/c2*2-1(3)4-5;1-5(2,3)4/h2*5H,(H4,2,3,4);(H2,1,2,3,4)

Clé InChI

MTGDDPZRXSDPFH-UHFFFAOYSA-N

Actions biochimiques/physiologiques

An early antitumor agent. Oxidation results in release of NO, and formation of other reactive oxygen species, including peroxynitrite and peroxyl radicals. Reacts with NO to form an adduct which is a potent and stable vasodilator.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Patrick Slama et al.
Journal of inorganic biochemistry, 103(3), 455-462 (2009-01-31)
N-Aryl-N'-hydroxyguanidines are compounds that display interesting pharmacological properties but their chemical reactivity remains poorly investigated. Some of these compounds are substrates for the heme-containing enzymes nitric-oxide synthases (NOS) and act as reducing co-substrates for the copper-containing enzyme Dopamine beta-Hydroxylase (DBH)
Daniel Mansuy et al.
Free radical biology & medicine, 37(8), 1105-1121 (2004-09-29)
Nitric oxide (NO) is a key inter- and intracellular molecule involved in the maintenance of vascular tone, neuronal signaling, and host response to infection. The biosynthesis of NO in mammals involves a two-step oxidation of L-arginine (L-Arg) to citrulline and
David Lefèvre-Groboillot et al.
The FEBS journal, 272(12), 3172-3183 (2005-06-16)
The binding of several alkyl- and aryl-guanidines and N-hydroxyguanidines to the oxygenase domain of inducible NO-synthase (iNOS(oxy)) was studied by UV/Vis difference spectroscopy. In a very general manner, monosubstituted guanidines exhibited affinities for iNOS(oxy) that were very close to those
Zhi-guo Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(9), 705-710 (2004-12-21)
To search for novel antiasthmatic agents. Coupling seratrodast (SD), an antiasthmatic drug, with several different types of NO donors including oxatriazoles, N-hydroxyguanidines and furoxans; evaluating the antiasthmatic effects of coupled compounds by determining their inhibitory activity of guinea pig asthma
Daniel Mansuy et al.
Drug metabolism reviews, 34(3), 593-606 (2002-09-07)
Microsomal cytochromes P450 and tetrahydrobiopterin (BH4) free-NOS II catalyze the oxidation of N-hydroxyguanidines by NADPH and O2 with formation of nitrogen oxides including NO. These reactions are not selective in terms of substrates, as they occur on most N-hydroxyguanidines, and
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