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Merck
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Principaux documents

F8932

Sigma-Aldrich

Fatostatin hydrobromide

≥98% (HPLC), powder

Synonyme(s) :

25B11 hydrobromide, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide, Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide

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About This Item

Formule empirique (notation de Hill):
C18H18N2S·HBr
Numéro CAS:
298197-04-3
Poids moléculaire :
375.33
Numéro MDL:
MFCD00760867
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

light yellow to yellow

Solubilité

DMSO: ≥10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

[s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br

InChI

1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H

Clé InChI

RJCFNQZVFUMORB-UHFFFAOYSA-N

Description générale

Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.

Application

Fatostatin hydrobromide has been used:
  • to study its anti-cancer activity and effects on mitotic microtubule spindle
  • to study its effects on stomatal development
  • to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

Actions biochimiques/physiologiques

Fatostatin hydrobromide is an SREBP inhibitor.
Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
075M4614V
074M4615V
090M4609

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Consulter la Bibliothèque de documents

Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling
Li X, et al.
Molecular Cancer Therapeutics, 13(4), 855-866 (2014)
Chih-Ming Huang et al.
Cells, 9(1) (2019-12-22)
: Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to investigate the therapeutic
Yumiko Sakai et al.
Development (Cambridge, England), 144(3), 499-506 (2017-01-15)
Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it
Inhibition of cell polarity establishment in stomatal asymmetric cell division using the chemical compound bubblin
Sakai Y, et al.
Development, dev-145458 (2017)
Jessica E Rexach et al.
Cell reports, 33(7), 108398-108398 (2020-11-19)
To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD, and PSP. We uncover a complex temporal trajectory of
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