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Key Documents

E6527

Sigma-Aldrich

Elastin, soluble from bovine neck ligament

salt-free, lyophilized powder

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About This Item

Numéro CAS:
9007-58-3
Numéro CE :
232-701-4
Numéro MDL:
MFCD02687372
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine neck ligament

Niveau de qualité

100

Forme

salt-free, lyophilized powder

Technique(s)

UV/Vis spectroscopy: suitable

Numéro d'accès UniProt

P04985

Température de stockage

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

Clé InChI

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Informations sur le gène

cow ... ELN(280781)

Description générale

Water-soluble powder prepared by method of Partrige, et al.

Application

Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Highly stable and hemocompatible protein now finding use in construction of biomaterials as a result of several strategies for its solubilization.

Actions biochimiques/physiologiques

Protein responsible for the elasticity of many tissues. It is especially important in blood vessels, where it comprises about 50% of the dry tissue weight.

Attention

Forms coacervate at pH 5.0 and 37 °C

Adéquation

Suitable for determination of elastolytic activity as described by Keller and Mandi.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Felix Cleemann et al.
Analytical chemistry, 80(11), 4170-4174 (2008-04-25)
A novel fluorescence polarization assay based on the natural fluorophore epicocconone has been developed. This assay allows the rapid and accurate determination of enzyme kinetic parameters as well as inhibition constants through the measurement of fluorescence anisotropy on the actual
J Tong et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 45(4), 364-372 (2013-02-12)
The main purpose of the present study is the investigation of gender differences in the biomechanical properties, thrombus age, mass fraction and key clinical factors of abdominal aortic aneurysms (AAAs). A total of 90 AAA samples (78 males and 12
Wolfgang G Mouton et al.
Swiss medical weekly, 143, w13755-w13755 (2013-02-28)
The ultrastructure of venous valves and walls in chronic venous disease was investigated. Consecutive patients were categorised into one of three groups (group A: patients with C1 venous disease in accordance with CEAP (Clinical severity, Etiology, Anatomy, Pathophysiology); group B:
Heath B Henninger et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(8), 1226-1233 (2013-04-05)
Elastin is a structural protein that provides resilience to biological tissues. We examined the contributions of elastin to the quasi-static tensile response of porcine medial collateral ligament through targeted disruption of the elastin network with pancreatic elastase. Elastase concentration and
Wei Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1028-1035 (2013-03-16)
Patients with elastin deficiency attributable to gene mutation (supravalvular aortic stenosis) or chromosomal microdeletion (Williams syndrome) are characterized by obstructive arteriopathy resulting from excessive smooth muscle cell (SMC) proliferation, mural expansion, and inadequate vessel size. We investigated whether rapamycin, an
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