D2926

Diphenyleneiodonium chloride

≥98%, Nitric oxide synthetase inhibitor, powder

• Synonyme(s) : DPI, Dibenziodolium chloride
• Formule empirique (notation de Hill) : C₁₂H₈ClI
• Numéro CAS: 4673-26-1
• Poids moléculaire : 314.55
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278032
• NACRES: NA.77
• MDL number: MFCD00214165
• Assay: ≥98%
• Form: powder

Propriétés

• Nom du produit: Diphenyleneiodonium chloride, ≥98%
• Quality Segment: 300
• assay: ≥98%
• form: powder
• mp: 278 °C
• solubility: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• storage temp.: room temp
• SMILES string: [Cl-].[I+]1c2ccccc2-c3ccccc13
• InChI: 1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
• InChI key: FCFZKAVCDNTYID-UHFFFAOYSA-M
• Gene Information: human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846) ; mouse ... Pik3r1(18708)

Description

Application

Diphenyleneiodonium chloride has been used as an NOX inhibitor:

• to study its effects on the reactive oxygen species (ROS) levels and also its inhibitory effects on killing tumor cells by neutrophils isolated from clinical malignant pleural effusion (MPE) samples
• as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor to confirm the variation in inflammation was secondary to overproduction of reactive oxygen species (ROS) in cells treated with doxorubicin (DOX) + flagellin (FL)
• as an NADPH oxidase (NOX) inhibitor to study its effects on palmitate (PA)-induced sphere-forming ability of HepG2 (hepatocellular carcinoma) cells

Biochem/physiol Actions

A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.

A potent reversible nitric oxide synthetase inhibitor from macrophages and endothelial cells.

Diphenyleneiodonium (DPI) can affect mitochondrial function. DPI can block neuron degeneration in Parkinson′s disease. It provides neuroprotection following focal cerebral ischemia. DPI can induce a chemo-quiescence phenotype in cancer stem-like cells, effectively inhibiting their proliferation.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)