D2926

Diphenyleneiodonium chloride

≥98%

• Synonyme(s) : DPI, Dibenziodolium chloride
• Formule empirique (notation de Hill): C₁₂H₈ClI
• Numéro CAS: 4673-26-1
• Poids moléculaire : 314.55
• Numéro MDL: MFCD00214165
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278032
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 300
• Pureté: ≥98%
• Forme: powder
• Pf: 278 °C
• Solubilité: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Température de stockage: room temp
• Chaîne SMILES: [Cl-].[I+]1c2ccccc2-c3ccccc13
• InChI: 1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1
• Clé InChI: FCFZKAVCDNTYID-UHFFFAOYSA-M
• Informations sur le gène: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) ; mouse ... Pik3r1(18708)

Description

Application

Diphenyleneiodonium chloride has been used as an NOX inhibitor:

• to study its effects on the reactive oxygen species (ROS) levels and also its inhibitory effects on killing tumor cells by neutrophils isolated from clinical malignant pleural effusion (MPE) samples
• as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor to confirm the variation in inflammation was secondary to overproduction of reactive oxygen species (ROS) in cells treated with doxorubicin (DOX) + flagellin (FL)
• as an NADPH oxidase (NOX) inhibitor to study its effects on palmitate (PA)-induced sphere-forming ability of HepG2 (hepatocellular carcinoma) cells

Actions biochimiques/physiologiques

A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.

Diphenyleneiodonium (DPI) can affect mitochondrial function. DPI can block neuron degeneration in Parkinson′s disease. It provides neuroprotection following focal cerebral ischemia. DPI can induce a chemo-quiescence phenotype in cancer stem-like cells, effectively inhibiting their proliferation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)