C3042

Corticotropin Releasing Factor human, rat

≥95% (HPLC), powder

• Synonyme(s) : CRF, CRH
• Formule empirique (notation de Hill): C₂₀₈H₃₄₄N₆₀O₆₃S₂
• Numéro CAS: 86784-80-7
• Poids moléculaire : 4757.45
• Numéro MDL: MFCD00213806
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human; rat
• Niveau de qualité: 200
• Essai: ≥95% (HPLC)
• Forme: powder
• Poids mol.: 4757.45
• Conditions de stockage: (Keep container tightly closed in a dry and well-ventilated place)
• Technique(s): activity assay: suitable
• Solubilité: water: 1.00-1.04 mg/mL, colorless
• Numéro d'accès UniProt: P06850
• Température de stockage: −20°C
• Clé InChI: VXFVFWFSJFSXHN-FAUHKOHMSA-N
• Informations sur le gène: human ... CRH(1392)

Description

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

Description générale

The corticotropin-releasing factor is a 41-amino-acid polypeptide.[1] It is expressed in neurons, the hypothalamus, and the amygdala.[2]

Research area: Neuroscience

Application

Corticotropin Releasing Factor human, rat has been used:

• as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants[3]
• as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells[4]
• in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture[5]
• in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus[6]

Actions biochimiques/physiologiques

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Corticotropin-releasing factor modulates stress responses.[7][1] It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.[8]Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[9] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[10]

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)