A6671

Actinonin

≥98% (TLC), powder, leucine aminopeptidase inhibitor

• Synonyme(s) : 3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
• Formule empirique (notation de Hill) : C₁₉H₃₅N₃O₅
• Numéro CAS: 13434-13-4
• Poids moléculaire : 385.50
• NACRES: NA.77
• PubChem Substance ID: 24278232
• UNSPSC Code: 12352200
• MDL number: MFCD00080257
• Beilstein/REAXYS Number: 1555250
• Assay: ≥98% (TLC)
• Form: powder

Propriétés

• Nom du produit: Actinonin,
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: ethanol: 50 mg/mL, clear, colorless
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
• InChI: 1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
• InChI key: XJLATMLVMSFZBN-UHFFFAOYSA-N
• Gene Information: human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)

Description

General description

Chemical structure: peptide

Application

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.

Biochem/physiol Actions

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)