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A0835

Sigma-Aldrich

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

Synonyme(s) :

Ac-DEVD-CHO

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About This Item

Formule empirique (notation de Hill):
C20H30N4O11
Numéro CAS:
169332-60-9
Poids moléculaire :
502.47
Numéro MDL:
MFCD00671412
Code UNSPSC :
12352209
ID de substance PubChem :
24890193
Nomenclature NACRES :
NA.32

Source biologique

synthetic

Niveau de qualité

100

Pureté

≥95%

Forme

powder

Couleur

white

Solubilité

H2O: 1 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

Clé InChI

UMBVAPCONCILTL-UHFFFAOYSA-N

Informations sur le gène

human ... CASP1(834) , CASP3(836) , CASP7(840) , CASP8(841)

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

Description générale

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Application

N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Actions biochimiques/physiologiques

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.
Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Florian Guisier et al.
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Prediction of treatment outcome of non-small cell lung cancer (NSCLC) with EGFR inhibitors on the basis of the genetic analysis of the tumor can be incorrect in case of rare or complex mutations, bypass molecular activation pathways, or pharmacodynamic variations.
Carles Solà-Riera et al.
Scientific reports, 9(1), 834-834 (2019-01-31)
Orthohantaviruses, previously known as hantaviruses, are zoonotic viruses that can cause hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS) in humans. The HPS-causing Andes virus (ANDV) and the HFRS-causing Hantaan virus (HTNV) have anti-apoptotic effects. To investigate
Yong-Bo Li et al.
Insect biochemistry and molecular biology, 79, 73-86 (2016-10-26)
Autophagy regulates cell survival (or cell death in several cases), whereas apoptosis regulates cell death. However, the relationship between autophagy and apoptosis and the regulative mechanism is unclear. We report that steroid hormone 20-hydroxyecdysone (20E) promotes switching from autophagy to
Elisa I Glover et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 35(2), 125-133 (2010-04-13)
A number of studies in rodents suggest that disuse atrophy results from a large increase in proteolysis affected by, or accompanying, increased oxidative stress. Little information is available, however, about the effects of immobilization on markers of muscle protein breakdown
An-Cheng Huang et al.
Journal of ethnopharmacology, 194, 1043-1050 (2016-11-12)
Bufalin, a component of Chan Su (frog), has been shown to have biological activities including anti-tumor effects. Gefitinib has been used as an anti-cancer drug in lung cancer patients; however, some patients eventually become gefitinib resistant. In this study, we
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