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36799

Sigma-Aldrich

7-(Diethylamino)coumarin-3-carboxylic acid

BioReagent, suitable for fluorescence, ≥98.0% (HPCE)

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About This Item

Formule empirique (notation de Hill):
C14H15NO4
Numéro CAS:
50995-74-9
Poids moléculaire :
261.27
Numéro Beilstein :
6145963
Numéro MDL:
MFCD00068721
Code UNSPSC :
12352106
ID de substance PubChem :
57649663
Nomenclature NACRES :
NA.32

Gamme de produits

BioReagent

Pureté

≥98.0% (HPCE)

Pf

222-224 °C (dec.) (lit.)

Solubilité

DMF: soluble
DMSO: soluble

Fluorescence

λex 409 nm; λem 473 nm in 0.1 M Tris pH 9.0

Adéquation

suitable for fluorescence

Chaîne SMILES 

CCN(CC)c1ccc2C=C(C(O)=O)C(=O)Oc2c1

InChI

1S/C14H15NO4/c1-3-15(4-2)10-6-5-9-7-11(13(16)17)14(18)19-12(9)8-10/h5-8H,3-4H2,1-2H3,(H,16,17)

Clé InChI

WHCPTFFIERCDSB-UHFFFAOYSA-N

Application

7-(Diethylamino)coumarin-3-carboxylic acid (7-DCCA) may be used to study its photophysical properties in various solvents and solvent mixtures and as a fluorescent label for amine modification and protein conjugation

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Autres remarques

Fluorescent label for amine modification and protein conjugation

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Ilaria Catusi et al.
International journal of molecular sciences, 21(22) (2020-11-15)
Maternal uniparental disomy of chromosome 7 is present in 5-10% of patients with Silver-Russell syndrome (SRS), and duplication of 7p including GRB10 (Growth Factor Receptor-Bound Protein 10), an imprinted gene that affects pre-and postnatal growth retardation, has been associated with
Alicia S Kriete et al.
Interface focus, 9(4), 20190013-20190013 (2019-07-03)
Urinary incontinence is a significant challenge for women who are affected by it. We propose augmenting the tissue structure to restore normal biomechanics by molecularly engineering the tissue using a novel family of biomimetic proteoglycans (BPGs). This work examines the
Simone Kunzelmann et al.
Biochemistry, 49(5), 843-852 (2009-12-24)
A single-stranded DNA binding protein (SSB), labeled with a fluorophore, interacts with single-stranded DNA (ssDNA), giving a 6-fold increase in fluorescence. The labeled protein is the adduct of the G26C mutant of the homotetrameric SSB from Escherichia coli and a
Keisuke Ikeda et al.
Biochemical and biophysical research communications, 370(3), 525-529 (2008-04-09)
Amyloid beta-protein (Abeta) has been reported to interact with a variety of lipid species, although the thermodynamic driving force remains unclear. We investigated the binding of Abetas labeled with the dye diethylaminocoumarin (DAC-Abetas) to lipid bilayers under various conditions. DAC-Abeta-(1-40)
Tiffany P Gustafson et al.
Chemical communications (Cambridge, England), 49(7), 680-682 (2012-12-12)
Nanothermometers composed from a gold nanorod core, temperature sensitive linker and fluorescent dye are reported. The nanothermometers have low fluorescence due to a self-quenching mechanism at temperatures below 50 °C and become highly fluorescence above 70 °C.
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