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01897

Sigma-Aldrich

Adenosine 5′-diphosphate disodium salt

≥90%

Synonyme(s) :

ADPdisodium salt, Disodium 5′-ADP, Disodium adenosine 5′-diphosphate, 5′-ADP-Na2

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About This Item

Formule empirique (notation de Hill):
C10H13N5Na2O10P2
Numéro CAS:
16178-48-6
Poids moléculaire :
471.16
Numéro Beilstein :
7563620
Numéro CE :
240-314-7
Numéro MDL:
MFCD00066635
Code UNSPSC :
41106305
eCl@ss :
32160414
ID de substance PubChem :
329747370
Nomenclature NACRES :
NA.51

Pureté

≥90%

Forme

powder or crystals

Activité optique

[α]20/D −29.6±1°, c = 0.5% in 0.5 M Na2HPO4

Impuretés

≤10% water

Température de stockage

−20°C

Chaîne SMILES 

[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H15N5O10P2.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

Clé InChI

ORKSTPSQHZNDSC-IDIVVRGQSA-L

Application

Adenosine 5′-diphosphate disodium salt has been used as a purinergic G protein-coupled receptor P2Y12 agonistin platelet activation tests in blood samples.

Actions biochimiques/physiologiques

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by ATP synthases. ADP affects platelet activation through its interaction with purinergic receptors P2Y1 and P2Y12. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Cécile H Kicken et al.
PloS one, 12(2), e0172265-e0172265 (2017-02-17)
Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive. We have optimized the flow cytometry-based quantification of agonist
Sven Van Poucke et al.
PloS one, 13(6), e0193657-e0193657 (2018-06-22)
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal peroperative chemotherapy (HIPEC), indicated for patients with peritoneal metastases from digestive or gynecological malignancies alike, demonstrates a considerable impact on hemostatic metabolism, both on platelet and on coagulation level. The potential hemostatic interference in
Dana Huskens et al.
PloS one, 13(2), e0192079-e0192079 (2018-02-02)
Platelet function testing with flow cytometry has additional value to existing platelet function testing for diagnosing bleeding disorders, monitoring anti-platelet therapy, transfusion medicine and prediction of thrombosis. The major challenge is to use this technique as a diagnostic test. The
Lihui Long et al.
Experimental and therapeutic medicine, 19(5), 3177-3188 (2020-04-09)
The underlying mechanism of the myocardial protective effect of fisetin was studied in a rat ischemia/reperfusion injury model. Sprague-Dawley rats were randomly assigned to seven groups and pretreated with different solutions by gavage administration. A rat model of cardiac ischemia/reperfusion
Béatrice Hechler et al.
Purinergic signalling, 7(3), 293-303 (2011-07-28)
Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agents act in a positive
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