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Principaux documents

Y0000359

Acebutolol impurity B

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl}acetamide, Diacetolol

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About This Item

Formule empirique (notation de Hill):
C16H24N2O4
Numéro CAS:
22568-64-5
Poids moléculaire :
308.37
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

acebutolol

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

InChI

1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

Clé InChI

AWOGXJOBNAWQSF-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1000601

Acebutolol hydrochloride, United States Pharmacopeia (USP) Reference Standard

1000612

Acebutolol Related Compound A, United States Pharmacopeia (USP) Reference Standard

A0040000

Acebutolol hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0000127

Acebutolol impurity C, European Pharmacopoeia (EP) Reference Standard

Y0000128

Acebutolol impurity I, European Pharmacopoeia (EP) Reference Standard

1000699

Acebutolol Related Compound I, United States Pharmacopeia (USP) Reference Standard

1000623

Acebutolol Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1907

Acebutolol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2824

Acebutolol Related Compound A

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Consulter la Bibliothèque de documents

D R Abernethy et al.
American heart journal, 109(5 Pt 2), 1120-1125 (1985-05-01)
Studies in various animal models have shown acebutolol to be a relatively cardioselective beta-adrenoceptor-blocking agent possessing both partial agonist and membrane-stabilizing activities. The latter property may not be significant at clinically used doses. Acebutolol has both antihypertensive and antiarrhythmic effects.
M Piquette-Miller et al.
Agents and actions, 37(3-4), 290-296 (1992-11-01)
Disease states such as arthritis may interact with the kinetics of beta-blockers. Acebutolol (AC) is a chiral beta-blocker which is available as a racemate. The beneficial properties of AC, however, is attributed mainly to the S-(+)-enantiomer. The disposition of AC
Jari J Lilja et al.
British journal of clinical pharmacology, 60(6), 659-663 (2005-11-25)
We aimed to investigate effects of grapefruit juice on acebutolol pharmacokinetics. In a randomized cross-over study, 10 healthy subjects ingested 200 mL grapefruit juice or water three times daily for 3 days and twice on day 4. On day 3
M Piquette-Miller et al.
Journal of clinical pharmacology, 32(2), 148-156 (1992-02-01)
Acebutolol (AC) is a chiral beta-blocker that is metabolized to an equipotent chiral metabolite, diacetolol (DC). A stereoselective disposition of AC and DC enantiomers has recently been reported in young healthy subjects. As many physiologic properties affecting drug disposition are
M S Thomas et al.
European journal of clinical pharmacology, 29(6), 679-683 (1986-01-01)
The beta-adrenergic selectivity of diacetolol, the major metabolite of acebutolol, has been compared with that of acebutolol, metoprolol and propranolol in 11 normal subjects. Bronchial and cardiac beta-adrenoceptor blockade were assessed on separate occasions after diacetolol 600 mg, acebutolol 400
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