SCCAR10064
Assay Ready LX-2 Human Hepatic Stellate Cell Line
Human
Synonyme(s) :
assay ready hepatic stellate cells, assay ready hepatocytes, hepatic fibrosis cell line, hepatic stellate cell line, hepatocyte cell line
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
41106514
Nomenclature NACRES :
NA.81
Produits recommandés
product name
Assay Ready LX-2 Human Hepatic Stellate Cell Line,
Source biologique
human
Niveau de qualité
Conditionnement
vial of 1 vial
Fabricant/nom de marque
Millipore
Technique(s)
cell culture | stem cell: suitable
Conditions d'expédition
liquid nitrogen
Température de stockage
−196°C
Description générale
Hepatic stellate cells are a major cell type responsible for liver fibrosis following their activation into fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for human studies.
LX-2 was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early passaged cells in low serum media conditions.
Immortalized LX-2 was established by Xu et al to overcome issues of culture variability and to provide a stable and unlimited source of human hepatic stellate cells that are homogeneous. These cell lines have been extensively characterized and retain key features of cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis, making them highly suitable for culture based studies of human hepatic fibrosis.
LX-2 was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early passaged cells in low serum media conditions.
Immortalized LX-2 was established by Xu et al to overcome issues of culture variability and to provide a stable and unlimited source of human hepatic stellate cells that are homogeneous. These cell lines have been extensively characterized and retain key features of cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis, making them highly suitable for culture based studies of human hepatic fibrosis.
Caractéristiques et avantages
LX-2 cells retain key features of human hepatic stellate cells including cytokine signaling, retinoid metabolism, and fibrogenesis. **SCCAR10064 cells are non-expandable and packaged at high density to enable readiness for hepatic fibrosis and other relevant assays without propagation or passage.
Description de la cible
This product contains cells sold under a consumable label license and which may not be propagated. For the equivalent expandable, bankable LX-2 cell line, please see <IS7_PDP/PFPLink_from_Module_content target="https://www.sigmaaldrich.com/US/en/product/mm/scc064">SCC064</IS7_PDP/PFPLink_from_Module_content>.
Hepatic stellate cells are an essential cell phenotype responsible for liver fibrosis following their activation to fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for the development of therapeutics.
The LX-2 cell line was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early-passage cells in low serum media conditions.
Hepatic stellate cells are an essential cell phenotype responsible for liver fibrosis following their activation to fibrogenic myofibroblast-like cells in diseases such as chronic alcoholism, hepatitis B and C, fatty liver disease, obesity and diabetes. There is an increasing need for renewable cell culture models that faithfully recapitulate their in vivo phenotype, particularly for the development of therapeutics.
The LX-2 cell line was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early-passage cells in low serum media conditions.
Stockage et stabilité
LX-2 cells should be stored in liquid nitrogen.
Autres remarques
This product is intended for sale as a consumable. It may not be propagated, passaged, or expanded and is subject to the terms of the “Assay Ready Cells Research Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique