341274-M

Factor H, Human

Factor H, Human, is a single-chain multi-functional glycoprotein that regulates formation and function of complement C3 and C5 convertase enzymes.

• Synonyme(s) : β _1H Globulin, β_1H Globulin
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (SDS-PAGE)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles
• Impuretés: IgG, IgA, IgM, Factor I, Factor B, Factor P, C3, C4, or albumin, trace (Ouchterlony)
• Température de stockage: −70°C

Description

Description générale

Native factor H from human serum. Single-chain glycoprotein present in normal human serum at about 500 µg/ml. Regulates formation and function of complement C3 and C5 convertase enzymes. A C3b-binding protein, not an enzyme. Regulatory activity is attributed to its ability to recognize and bind to C3b fragments.

Native factor H from human serum. Single-chain multi-functional glycoprotein present in normal human serum at about 500 µg/ml. Regulates formation and function of complement C3 and C5 convertase enzymes. A C3b-binding protein that does not exhibit enzymatic activity. Regulatory activity is attributed to its ability to recognize and bind to C3b fragments.

Avertissement

Toxicity: Standard Handling (A)

Forme physique

In PBS, pH 7.2.

Notes préparatoires

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Autres remarques

Zipfel, P.F., et al. 1999. Immunopharmacology 42, 53.
Pangburn, M.K. and Muller-Eberhard, H.J. 1984. Springer Semin. Immunopathol. 7, 163.
Fearon, D.T. and Austen, K.F. 1977. Proc. Natl. Acad. Sci. USA 74, 1683.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable