QBD10503

Azido-dPEG^®₈-NHS ester

• Synonyme(s) : 2,5-Dioxo-1-pyrrolidinyl 3-[(23-azido-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]propanoate, Polyethylene glycol
• Formule empirique (notation de Hill): C₂₃H₄₀N₄O₁₂
• Numéro CAS: 1204834-00-3
• Poids moléculaire : 564.58
• Numéro MDL: MFCD13184949
• Code UNSPSC : 12161502
• ID de substance PubChem : 329823932
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: >90%
• Forme: solid or viscous liquid
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: cross-linking reagent; reaction type: click chemistry
• Groupe fonctionnel: NHS ester; azide
• Architecture des polymères: shape: linear; functionality: heterobifunctional
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Description

Caractéristiques et avantages

The azido-dPEG^®₈-NHS ester contains an azide function on one end of a single molecular weight dPEG^® spacer(32.2 Å) and a reactive group (NHS ester) on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. N-hydroxysuccinimide (NHS) ester readily react with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable