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Merck
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Principaux documents

934119

Sigma-Aldrich

Ovine collagen

SPDP functionalized, low endotoxin

Synonyme(s) :

CollOvine™-SPDP

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About This Item

Numéro CAS:
9007-34-5
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.28

Niveau de qualité

100

Forme

lyophilized

Impuretés

Bioburden, none detected
≤0.1 EU/mg Endotoxin

Couleur

white to off-white

Groupe fonctionnel

SPDP

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Description générale

Collagen is a major component of the extracellular matrix (ECM) and offers low immunogenicity, a porous structure, good permeability, and biocompatibility to promote cell viability, adhesion, spreading, proliferation and differentiation.

Low endotoxin SPDP functionalized collagen derived from ovine can be used for the covalent conjugation with sulfhydryl-containing molecules. The primary amine groups (lysine residues) of the collagen are reacted with succinimidyl 3-(2-pyridyldithio)propionate (SPDP) to yield collagen derived with a cleavable disulfide bond. The cleaved linker can react with other species containing containing free sulhydryl groups (i.e. cysteine residues) which are commonly found in many naturally occurring protein or peptide sequences.

Application

  • 3D bioprinting
  • Tissue engineering
  • Drug delivery
  • Regenerative medicine
  • Cell culture, encapsulation, expansion and differentiation

Caractéristiques et avantages

  • Certified Disease Free Sheep
  • 93-97% Type I Collagen
  • 3-7% Type III Collagen
  • 99% Purity
  • Prion Free

Informations légales

CollOvine is a trademark of OviGenex LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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Consulter la Bibliothèque de documents

Collagen as Bioink for Bioprinting: A Comprehensive Review
Osidak E O, et al.
International Journal of Bioprinting, 6(3), 270-270 (2020)
Egor Olegovich Osidak et al.
International journal of bioprinting, 6(3), 270-270 (2020-10-23)
Biomaterials made using collagen are successfully used as a three-dimensional (3D) substrate for cell culture and considered to be promising scaffolds for creating artificial tissues. An important task that arises for engineering such materials is the simulation of physical and
Jana Stepanovska et al.
Biomedicines, 9(9), 1137-1137 (2021-09-29)
Bioprinting is a modern tool suitable for creating cell scaffolds and tissue or organ carriers from polymers that mimic tissue properties and create a natural environment for cell development. A wide range of polymers, both natural and synthetic, are used
Elizabeth E Antoine et al.
Tissue engineering. Part B, Reviews, 20(6), 683-696 (2014-06-14)
Type I collagen hydrogels have been used successfully as three-dimensional substrates for cell culture and have shown promise as scaffolds for engineered tissues and tumors. A critical step in the development of collagen hydrogels as viable tissue mimics is quantitative
Atiqah Salleh et al.
Biomedicines, 10(4), 816-816 (2022-04-24)
Tissue engineering products have grown rapidly as an alternative solution available for chronic wound and burn treatment. However, some drawbacks include additional procedures and a lack of antibacterial properties that can impair wound healing, which are issues that need to

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