905186

(9-Bromononyl)triphenylphosphonium bromide

• Synonyme(s) : Bromononane TPP mitochondrial tag, Mitochondria-targeting probe building block, Phosphonium lipocation tag
• Formule empirique (notation de Hill): C₂₇H₃₃Br₂P
• Numéro CAS: 90052-38-3
• Poids moléculaire : 548.33
• Code UNSPSC : 12352200

Propriétés

• Forme: liquid
• Température de stockage: 2-8°C
• InChI: 1S/C27H33BrP.BrH/c28-23-15-4-2-1-3-5-16-24-29(25-17-9-6-10-18-25,26-19-11-7-12-20-26)27-21-13-8-14-22-27;/h6-14,17-22H,1-5,15-16,23-24H2;1H/q+1;/p-1
• Clé InChI: ACKJFSDDEOFXHT-UHFFFAOYSA-M

Description

Application

Mitochondria perform several functions in the cell, and dysfunction has been implicated in various organ systems and disease states, including neurodegenerative disorders and cancers. The targeting of small molecules to the mitochondria can help to probe and better understand this relationship. This bromononane triphenylphosphine (TPP) tag is conjugated to small molecules to localize them to the mitochondria in cells where the TPP cations facilitate both cellular uptake and accumulation in the mitochondria.

Autres remarques

Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

Targeting lipophilic cations to mitochondria

Photoswitchable polyfluorophores based on perylenemonoimide-dithienylethene conjugates as super-resolution MitoTrackers

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable