902667

Propargyl-PEG6-acid

• Synonyme(s) : 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• Formule empirique (notation de Hill): C₁₆H₂₈O₈
• Numéro CAS: 1951438-84-8
• Poids moléculaire : 348.39
• Numéro MDL: MFCD28950778
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Essai: ≥95%
• Forme: liquid
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: cross-linking reagent
• Indice de réfraction: n/D 1.469
• Groupe fonctionnel: alkyne; carboxylic acid
• Température de stockage: −20°C
• Chaîne SMILES: OC(CCOCCOCCOCCOCCOCCOCC#C)=O
• InChI: 1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
• Clé InChI: XRSJYQQOJNYUDV-UHFFFAOYSA-N

Description

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable