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901297

Sigma-Aldrich

Polyester bis-MPA dendron 4 NHBoc, 1 azide (core)

generation 2

Synonyme(s) :

Bis-MPA dendron, PFd-G2-Azide-NH-BOC

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About This Item

Formule empirique (notation de Hill):
C53H89N7O22
Poids moléculaire :
1176.31
Code UNSPSC :
12352125
Nomenclature NACRES :
NA.23

Description

4 NHBoc, 1 azide (core)

Niveau de qualité

100

Forme

solid

Poids mol.

generation 2

Nb de groupes de surface

4

Couleur

white to off-white

Groupe fonctionnel

azide (core)

Température de stockage

−20°C

Description générale

  • Polymer architecture: Dendron
  • End Group Functionality: Boc-protected amine
  • Boc : tert-Butyloxycarbonyl
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

Application

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the azide-core can be readily conjugated using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

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