V4765
Valnoctamide
≥98% (NMR)
Synonym(s):
2-ethyl-3-methyl-pentanamide, Axiquel, Nirvanil
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C8H17NO
CAS Number:
Molecular Weight:
143.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (NMR)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
SMILES string
CCC(C)C(CC)C(N)=O
InChI
1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)
InChI key
QRCJOCOSPZMDJY-UHFFFAOYSA-N
Application
Valnoctamide has been used:
- as a mood stabilizer to study its anti-cytomegalovirus (anti-CMV) effects in newborn mice brain
- as a hypnotic sedative to study its cytotoxic effects on oligodendrocyte precursor cells (OPCs) and human oligodendroglioma cell line (HOG)
- as a mood stabilizer to study its effects on inhibition of human cytomegalovirus
Biochem/physiol Actions
Valproic acid (VPA) and derivatives such as valpromide and valnoctamide are anti-convulsant, mood stabilizing drugs, believed to function as indirect GABA agonists by inhibiting the transamination of GABA.
Valnoctamide exhibits anti-cytomegalovirus (anti-CMV) properties. It has therapeutic effects against status epilepticus (SE) and neuropathic pain. Valnoctamide also shows therapeutic effects against bipolar disorders.
Features and Benefits
This compound is featured on the Glutamate/GABA Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Amidic derivatives of valproic acid as antiviral in HSV-1-infected oligodendrocytes.
Praena B, et al.
Antiviral Research, 54(29), 99-102 (2019)
Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, et al.
Virology, 499(29), 121-135 (2016)
M Bialer
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 187-192 (1999-10-16)
Valproic acid (VPA) is one of the major antiepileptic drugs. However, its anticonvulsant potency is less than the other three major antiepileptic drugs. Furthermore, VPA causes two rare but severe side effects: teratogenicity and hepatotoxicity. We utilized pharmacokinetic considerations in
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V4765-25MG | 04061832561462 |
| V4765-5MG | 04061832561479 |