T6950

Tizanidine hydrochloride

≥98% (HPLC), powder

• Synonym(s): 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
• Empirical Formula (Hill Notation): C₉H₉Cl₂N₅S
• CAS Number: 64461-82-1
• Molecular Weight: 290.17
• NACRES: NA.77
• PubChem Substance ID: 24724634
• UNSPSC Code: 12352200
• MDL number: MFCD00798231
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: H₂O: >20 mg/mL
• originator: Acorda Therapeutics
• SMILES string: Cl[H].Clc1ccc2nsnc2c1NC3=NCCN3
• InChI: 1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
• InChI key: ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

Tizanidine hydrochloride has been used for developing spectrophotometric methods for the validation of skeletal muscle relaxants.

Biochem/physiol Actions

α₂-adrenoceptor agonist.

Tizanidine hydrochloride is known to function as a skeletal muscle relaxant that acts centrally. Furthermore, this relaxant functions at spinal and supraspinal levels to block excitatory interneurons. This drug is used for the symptomatic relief of spasticity and painful muscle spasms.

Features and Benefits

This compound was developed by Acorda Therapeutics. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Tizanidine hydrochloride is soluble in water at a concentration that is greater than 20 mg/ml.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Faceshields, Gloves