This product may be stored at room temperature in the powdered format. The solution stability of this material has not been determined. However, various external sources indicate that prepared solutions are stable up to 1 month when stored tightly sealed in aliquots at -20°C. This information has not been validated.
M5441
Mibefradil dihydrochloride hydrate
≥98% (HPLC), powder, T-type Ca²⁺ channel blocker
Synonym(s):
(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate
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About This Item
Empirical Formula (Hill Notation):
C29H38FN3O3 · 2HCl · xH2O
CAS Number:
Molecular Weight:
568.55 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Pricing and availability is not currently available.
Product Name
Mibefradil dihydrochloride hydrate, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
H2O: soluble >20 mg/mL, absolute ethanol: insoluble
originator
Roche
SMILES string
O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C
InChI
1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1
InChI key
IZSWBBGKLWFDOC-YKXHUFBBSA-N
Application
Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.
Biochem/physiol Actions
Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels. It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.
Ro 40-5967 is a T-type Ca2+ channel blocker; antihypertensive.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: soluble >20 mg/mL, absolute ethanol: insoluble | solubility H2O: ≥10 mg/mL | solubility H2O: 13 mg/mL | solubility DMSO: ≥22 mg/mL |
| storage condition desiccated | storage condition - | storage condition desiccated | storage condition desiccated |
| color white | color white to off-white | color white | color white to tan |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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At what temperature should the compound be stored in powder for? And at what temperature in Solution?
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