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3,4-Dichloroisocoumarin

Name: 3,4-Dichloroisocoumarin
Brand: SIGMA

≥98% (TLC), Serine protease inhibitor, powder

Synonym(s):

3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one

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About This Item

Empirical Formula (Hill Notation):

C₉H₄Cl₂O₂

CAS Number:

51050-59-0

Molecular Weight:

215.03

NACRES:

NA.77

PubChem Substance ID:

24278386

UNSPSC Code:

12352202

MDL number:

MFCD00036960

Beilstein/REAXYS Number:

6802625

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Properties

Product Name

3,4-Dichloroisocoumarin, serine protease inhibitor

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H

InChI key

SUGXUUGGLDCZKB-UHFFFAOYSA-N

Description

General description

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Application

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.

Preparation Note

Half-life = 20 min at pH 7.5.

Other Notes

Effective concentration 5-100 μM.

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This Item	E1379	SML3559	T6137
Sigma-Aldrich D7910 3,4-Dichloroisocoumarin	Sigma-Aldrich E1379 7-Ethoxycoumarin	Sigma-Aldrich SML3559 LAU-0901	Sigma-Aldrich T6137 Trioxsalen
description serine protease inhibitor	description -	description ≥98% (HPLC)	description ≥98% (HPLC), powder
assay ≥98% (TLC)	assay ≥99.45% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
form powder	form powder	form powder	form powder
solubility ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow	solubility 95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility DMSO: 2 mg/mL, clear	solubility chloroform: soluble 50 mg/mL, clear, colorless to faintly yellow
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. −20°C

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Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H301,H315,H319,H335

Precautionary Statements

P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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