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D6382

Sigma-Aldrich

N,N-Dimethylglycine hydrochloride

≥98%, suitable for ligand binding assays

Synonym(s):

N,N-Dimethylaminoacetic acid hydrochloride

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About This Item

Linear Formula:
(CH3)2NCH2COOH · HCl
CAS Number:
Molecular Weight:
139.58
Beilstein:
3910578
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product name

N,N-Dimethylglycine hydrochloride,

Assay

≥98%

Quality Level

form

powder

technique(s)

ligand binding assay: suitable

color

white

mp

189-194 °C (lit.)

SMILES string

Cl.CN(C)CC(O)=O

InChI

1S/C4H9NO2.ClH/c1-5(2)3-4(6)7;/h3H2,1-2H3,(H,6,7);1H

InChI key

FKASAVXZZLJTNX-UHFFFAOYSA-N

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Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Characterization of osmolyte βine synthesizing sarcosine dimethylglycineN-methyltransferase from Methanohalophilus portucalensis.
Chen SY, Lai MC, Lai SJ, Lee YC.
Applied Microbiology, 191, 735-743 (2009)
Shuichi Setoguchi et al.
Molecules (Basel, Switzerland), 25(3) (2020-02-06)
The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel N,N-dimethylglycine
A J Hoorn
Mutation research, 222(4), 343-350 (1989-04-01)
Dimethylglycine (DMG) and the chemically related amino acids glycine, sarcosine (monomethylglycine) and betaine (trimethylglycine) were tested in Salmonella typhimurium strain TA100 after treatment with sodium nitrite under acidic conditions using a modified Ames Salmonella/microsome assay as reported by Colman et
Jing-Fang Zhu et al.
The journal of physical chemistry. B, 116(1), 113-119 (2011-12-14)
The experimental and theoretical enthalpies of formation of several structural-similar glycine-based sulfate/bisulfate amino acid ionic liquids including glycine sulfate (Gly(2)SO(4), 1), glycine bisulfate (GlyHSO(4), 2), N,N-dimethylglycine sulfate ([DMGly](2)SO(4), 3), N,N-dimethylglycine bisulfate ([DMGly]HSO(4), 4), N,N-dimethylglycine methyl ester sulfate ([DMGlyC(1)](2)SO(4), 5), N,N-dimethylglycine
Jian Yan et al.
The American journal of clinical nutrition, 95(5), 1060-1071 (2012-03-16)
In 1998 choline Adequate Intakes of 425 and 450 mg/d were established for nonpregnant and pregnant women, respectively. However, to our knowledge, no dose-response studies have been conducted to evaluate the effects of pregnancy or maternal choline intake on biomarkers

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