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Merck

A9847

Angiopoietin-2 human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

Ang-2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Biological source:
human
Recombinant:
expressed in NSO cells
Assay:
>97% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
66 kDa by SDS-PAGE (reducing and non-reducing conditions), 66 kDa by SDS-PAGE
Impurities:
endotoxin, tested
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biological source

human

Quality Level

recombinant

expressed in NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

66 kDa by SDS-PAGE (reducing and non-reducing conditions), 66 kDa by SDS-PAGE

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... ANGPT2(285)

Biochem/physiol Actions

This ligand is a naturally occurring inhibitor of angiopoietin-1 and Tie-2 both in vivo and in vitro, and has important roles in embryogenic angiogenesis and maintaining the integrity of adult vasculature.

Physical form

Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 500 mM NaCl, 0.1% PEG-8000, 0.2% CHAPS, pH 7.0 containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured a competitive binding assay.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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B Witzenbichler et al.
The Journal of biological chemistry, 273(29), 18514-18521 (1998-07-11)
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated, and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to be defined. In this study we
Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1.
Yang, et al.
Cell Death & Disease, 14, 344-344 (2023)
Hsiu-Mei Chen et al.
Oncotarget, 6(17), 14940-14952 (2015-04-25)
Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib may inhibit two critical lymphangiogenic signaling receptors VEGFR-3 and TIE-2. However



Global Trade Item Number

SKUGTIN
A9847-25UG04061833412565