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Nicarbazin

VETRANAL®, analytical standard

Synonym(s):

N,N′-bis(4-Nitrophenyl)urea compound with 4,6-dimethyl-2-pyrimidinone

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About This Item

Empirical Formula (Hill Notation):
C13H10N4O5 · C6H8N2O
CAS Number:
330-95-0
Molecular Weight:
426.38
EC Number:
206-359-1
MDL number:
MFCD00867204
UNSPSC Code:
41116107
PubChem Substance ID:
329754190
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

Cc1cc(C)nc(O)n1.[O-][N+](=O)c2ccc(NC(=O)Nc3ccc(cc3)[N+]([O-])=O)cc2

InChI

1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)

InChI key

UKHWDRMMMYWSFL-UHFFFAOYSA-N

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General description

Nicarbazin, an anti-coccidial drug, is an equimolar mixture of 4,4′-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethylpyrimidine (HDP). It is used for prophylactic treatment of coccidiosis in poultry birds.

Application

Nicarbazin may be used as a reference standard for the determination of nicarbazin residues in samples of chicken tissues, poultry feed, eggs and litter by high performance liquid chromatography (HPLC) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Caution

store under Argon

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK4402
BCCH5923
BCCF9120
BCBZ8824
BCBR5688V

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Efficient HPLC method for the determination of nicarbazin, as dinitrocarbanilide in broiler liver.
Capurro E, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 822(1-2), 154-159 (2005)
Surface plasmon resonance biosensor screening of poultry liver and eggs for nicarbazin residues.
Mccarney B, et al.
Analytica Chimica Acta, 483(1-2), 165-169 (2003)
A new and rapid method for the determination of nicarbazin residues in poultry feed, eggs and muscle tissue using supercritical fluid extraction and high performance liquid chromatography.
Matabudul D, et al.
Analyst, 124(4), 499-502 (1999)
Micro high-performance liquid chromatography for the determination of nicarbazin in chicken tissues, eggs, poultry feed and litter.
Draisci R, et al.
Journal of Chromatography A, 697(1-2), 407-414 (1995)
E D Peebles et al.
Poultry science, 91(9), 2183-2188 (2012-08-23)
Nicarbazin (NCZ), an effective anticoccidial widely used by the global broiler industry, is known to produce some side effects in broilers. Recent field observations have suggested that NCZ could be associated with spiking mortality syndrome, a disease of uncertain etiology
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