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Caspase-8 Inhibitor II

Name: Caspase-8 Inhibitor II
Brand: MM

InSolution

Synonym(s):

InSolution Caspase-8 Inhibitor II, Granzyme B Inhibitor III; Z-IE(OMe)TD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₄₃FN₄O₁₁

Molecular Weight:

654.68

NACRES:

NA.54

UNSPSC Code:

12352200

Form:

liquid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Quality Segment

100

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

−20°C

Description

General description

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO. Z-IETD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5). Also inhibits granzyme B.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-8

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Physical form

A 5 mM (250 µg/76 µl) solution of Z-IETD-FMK (Cat. No. 218759) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Analysis Note

≥98% (HPLC)

Other Notes

Martin, D.A., et al. 1998. J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998. FEBS Lett.425, 61.

Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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1 of 1

This Item	218753	264155	218773
Sigma-Aldrich 218840 Caspase-8 Inhibitor II	Sigma-Aldrich 218753 Caspase-5 Inhibitor I	Sigma-Aldrich 264155 Caspase-3 Inhibitor II	Sigma-Aldrich 218773 Caspase-8 Inhibitor I, Cell-Permeable
description InSolution	description Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8.	description The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.	description The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
form liquid	form solid	form solid	form lyophilized solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition OK to freeze, protect from light, desiccated (hygroscopic)	storage condition OK to freeze, desiccated	storage condition OK to freeze, desiccated	storage condition OK to freeze
shipped in wet ice	shipped in ambient	shipped in ambient	shipped in ambient

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - (refers to pure substance)

flash_point_c

87 °C - (refers to pure substance)

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