246573
6,7-Dihydroxycoumarin
98%
Synonym(s):
Cichorigenin, Esculetin
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About This Item
Empirical Formula (Hill Notation):
C9H6O4
CAS Number:
Molecular Weight:
178.14
Beilstein:
152788
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
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Assay
98%
form
powder
mp
271-273 °C (lit.)
SMILES string
Oc1cc2OC(=O)C=Cc2cc1O
InChI
1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
InChI key
ILEDWLMCKZNDJK-UHFFFAOYSA-N
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Dhamodaran Prabakaran et al.
Biochimie, 95(2), 366-373 (2012-10-20)
Diabetes mellitus is the most common serious metabolic disorder and it is considered to be one of the five leading causes of death in the world. Hyperglycemia-mediated oxidative stress plays a crucial role in diabetic complications. Hence, this study was
Daban Lu et al.
The Analyst, 136(21), 4447-4453 (2011-09-08)
An electrochemical sensor based on a CdSe nanoparticles (NPs)-decorated poly(diallyldimethylammonium chloride) (PDDA)-functionalized graphene (CdSe-PDDA-G) nanocomposite was fabricated for the sensitive detection of esculetin. The nanocomposite was characterized by X-ray diffraction (XRD), ultraviolet/visible spectra (UV-vis) and transmission electron microscopy (TEM). Cyclic
Eun-Sun Yun et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(7), 1335-1342 (2011-05-24)
The phenolic compound esculetin is known to inhibit the proliferation of vascular smooth muscle cells (VSMC). However, the signaling pathway by which esculetin mediates its molecular effects in VSMC remains to be identified. The present results suggest an unexpected role
Aline Witaicenis et al.
Chemico-biological interactions, 186(2), 211-218 (2010-04-13)
Coumarins comprise a broad class of phenolic compounds that influences the formation and scavenging of reactive oxygen species and the processes involving free radical-mediated injury. In light of the antioxidant and anti-inflammatory properties of esculetin and 4-methylesculetin, the aim of
Chen Wang et al.
Journal of neurochemistry, 121(6), 1007-1013 (2012-03-31)
Previous studies have demonstrated that a natural coumarin compound esculetin (Esc) possesses antioxidant, anti-tumor, and anti-inflammation activities and rescues cultured primary neurons from NMDA toxicity. In this study, we investigated the neuroprotective effects of Esc on cerebral ischemia/reperfusion (I/R) injury
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