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1612652

USP

Simethicone

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

α-(Trimethylsilyl)-ω-methylpoly[oxy(dimethylsilylene)] mixture with silicon dioxide, Antifoam A, Antifoam AF

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About This Item

Numéro CAS:
8050-81-5
Numéro MDL:
MFCD00134211
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

682,00 $

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Qualité

pharmaceutical primary standard

Famille d'API

simethicone

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[Si](O[Si](C)(C)C)(OC)(C)C.[Si](=O)=O

InChI

1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;

Clé InChI

AMTWCFIAVKBGOD-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide. [1]

Application

Simethicone USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph. [1]

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Krystyna Mojsiewicz-Pieńkowska
Journal of pharmaceutical and biomedical analysis, 58, 200-207 (2011-10-04)
The pharmaceutical industry is one of the more important sectors for the use of polydimethylsiloxanes (PDMS), which belong to the organosilicon polymers. In drugs for internal use, they are used as an active pharmaceutical ingredient (API) called dimeticone or simeticone.
Suriya Keeratichananont et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 93(8), 892-897 (2010-08-20)
Simethicone improves endoscopic visibility and diagnostic accuracy during colonoscopy and capsule endoscopy. Nevertheless, there have been limited data on its usefulness in esophagogastroduodenoscopy (EGD). To evaluate the effectiveness of simethicone on enhancing endoscopic visibility in patients undergoing EGD. 121 patients
Peng Zhao et al.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 26(9), 1130-1133 (2012-10-13)
To review the registration and technical data for breast implants. Recent literature concerning registration for breast implants was reviewed and analyzed. The aspects on registration for breast implants are complicated. The major aspects include providing technical data, establishing develop standard
Exfoliative erythrodermia induced by pantoprazole.
M Sánchez-Borges et al.
Allergologia et immunopathologia, 40(3), 194-195 (2011-05-31)
A Gallo et al.
Minerva medica, 102(2), 133-139 (2011-04-13)
Management of functional dyspepsia is still controversial. Different controlled trials reported a superiority of prokinetics, H2-receptor antagonists and proton-pump inhibitors over placebo; nevertheless, symptomatic improvement after therapy is often incomplete and some of these drugs possess serious side effects. The
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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