PHL89159

Apigenin

phyproof^® Reference Substance

• Synonyme(s) : 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
• Formule empirique (notation de Hill) : C₁₅H₁₀O₅
• Numéro CAS: 520-36-5
• Poids moléculaire : 270.24
• Beilstein: 262620
• Numéro MDL: MFCD00006831
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: primary reference standard
• Gamme de produits: phyproof^® Reference Substance
• Essai: ≥95.0% (HPLC)
• Forme: powder
• Fabricant/nom de marque: PhytoLab
• Pf: >300 °C (lit.)
• Chaîne SMILES: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• Clé InChI: KZNIFHPLKGYRTM-UHFFFAOYSA-N

Description

Description générale

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Actions biochimiques/physiologiques

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.

Autres remarques

This compound is commonly found in plants of the genus: achillea mentha pimpinella primula salvia silybum thymus

Informations légales

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3