V5390

VU0029251

≥98% (HPLC), powder

• Synonyme(s) : 6,7-Dihydro-2-(methylthio)-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine
• Formule empirique (notation de Hill): C₁₀H₁₁N₃S₂
• Poids moléculaire : 237.34
• Numéro MDL: MFCD00698485
• Code UNSPSC : 12352200
• ID de substance PubChem : 329829058
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥11 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CSc1nc(N)c2c3CCCc3sc2n1
• InChI: 1S/C10H11N3S2/c1-14-10-12-8(11)7-5-3-2-4-6(5)15-9(7)13-10/h2-4H2,1H3,(H2,11,12,13)
• Clé InChI: WDDBZCKBRCTSOZ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

VU0029251 is the first example of a partial mGluR5 partial antagonist that is not based on the MPEP scaffold. The compound displays a maximum inhibition of 50% activity, and cannot completely displace [3H] MPEP, suggesting that competition for MPEP is also allosteric, involving a unique site.

Caractéristiques et avantages

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable