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V1628

Sigma-Aldrich

Verrucarol

Synonyme(s) :

4β,15-Dihydroxy-12,13-epoxytrichothec-9-ene

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About This Item

Formule empirique (notation de Hill):
C15H22O4
Numéro CAS:
2198-92-7
Poids moléculaire :
266.33
Numéro MDL:
MFCD00056780
Code UNSPSC :
12352202
ID de substance PubChem :
24900718
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Température de stockage

−20°C

Chaîne SMILES 

[H][C@]12C[C@@H](O)C(C)([C@@]3(CO)CCC(C)=C[C@@]3([H])O1)C24CO4

InChI

1S/C15H22O4/c1-9-3-4-14(7-16)11(5-9)19-12-6-10(17)13(14,2)15(12)8-18-15/h5,10-12,16-17H,3-4,6-8H2,1-2H3/t10-,11-,12-,13?,14-,15?/m1/s1

Clé InChI

ZSRVBNXAPSQDFY-CXOCQXMISA-N

Actions biochimiques/physiologiques

Trichothecene mycotoxin that is a component of toxic mold. Esters of verrucarol have anti-tumor activity.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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S Barel et al.
Journal of pharmaceutical sciences, 79(6), 548-551 (1990-06-01)
Verrucarol is a simple trichothecene which is structurally related to T-2 and HT-2 toxins. Several macrocyclic trichothecenes which are ester derivatives of verrucarol possess antitumor activity. The pharmacokinetics of verrucarol has been studied in eight dogs following iv and oral
T L Brasel et al.
Applied and environmental microbiology, 71(1), 114-122 (2005-01-11)
Highly respirable particles (diameter, <1 microm) constitute the majority of particulate matter found in indoor air. It is hypothesized that these particles serve as carriers for toxic compounds, specifically the compounds produced by molds in water-damaged buildings. The presence of
B Harrach et al.
Applied and environmental microbiology, 41(6), 1428-1432 (1981-06-01)
A strain of Stachybotrys atra isolated from a field case of stachybotryotoxicosis in Hungary was cultured in Hungary. All of the compounds toxic to brine shrimp were separated from the culture extract by solvent partition, column chromatography, and preparative thin-layer
F S Chu et al.
Applied and environmental microbiology, 48(4), 781-784 (1984-10-01)
Immunization of rabbits with deoxyverrucarol (DOVE) conjugated to bovine serum albumin resulted in antibodies bound with either tritiated DOVE or diacetoxyscirpenol (DAS), but not with T-2 toxin. The affinity of antibodies with DOVE was found to be much higher than
T Tuomi et al.
Applied and environmental microbiology, 66(5), 1899-1904 (2000-05-02)
We analyzed 79 bulk samples of moldy interior finishes from Finnish buildings with moisture problems for 17 mycotoxins, as well as for fungi that could be isolated using one medium and one set of growth conditions. We found the aflatoxin
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