SRP8028

DR6 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Synonyme(s) : CD358, TNFRSF21, Tumor necrosis factor receptor superfamily member 21
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in HEK 293 cells
• Essai: >95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~80 kDa by SDS-PAGE
• Conditionnement: pkg of 50 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Impuretés: <0.1 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: O75509
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... TNFRSF21(27242)

Description

Description générale

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Forme physique

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 μL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

Autres remarques

The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable