SRP6390
CD80 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonyme(s) :
B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
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About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Source biologique
human
Produit recombinant
expressed in HEK 293 cells
Étiquette/Marqueur
6-His tagged (C-terminus)
Pureté
≥95% (SDS-PAGE)
Forme
lyophilized
Poids mol.
calculated mol wt 24.7 kDa
observed mol wt 45-75 kDa (DTT-reduced. Protein migrates due to different glycosylation. Val 35 is the predicted N-terminus.)
Conditionnement
pkg of 10 and 50 μg
pkg of 50 μg
Impuretés
<1 EU/μg endotoxin (LAL test)
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... CD80(941)
Description générale
B7-1 and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20 100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Forme physique
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Sophie V Pageon et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(37), E5454-E5463 (2016-08-31)
Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How
Jeremy D Waight et al.
Cancer cell, 33(6), 1033-1047 (2018-06-13)
The co-engagement of fragment crystallizable (Fc) gamma receptors (FcγRs) with the Fc region of recombinant immunoglobulin monoclonal antibodies (mAbs) and its contribution to therapeutic activity has been extensively studied. For example, Fc-FcγR interactions have been shown to be important for
Lei Li et al.
Scientific reports, 7(1), 13365-13365 (2017-10-19)
An effective cytotoxic T lymphocyte (CTL) response against intracellular pathogens is generally accomplished by immense CTL expansion and activation, which can destroy infected cells. Vigorous immune responses can lead to activation of bystander CD8
Jinsung Hong et al.
PloS one, 12(8), e0183174-e0183174 (2017-08-18)
Mechano-transduction is an emerging but still poorly understood component of T cell activation. Here we investigated the ligand-dependent contribution made by contractile actomyosin arcs populating the peripheral supramolecular activation cluster (pSMAC) region of the immunological synapse (IS) to T cell
Rolf Anton Klaasen et al.
Therapeutic drug monitoring, 41(1), 11-18 (2019-01-12)
Belatacept (Nulojix; Bristol-Myers Squibb, New York, NY) is a biological immunosuppressive drug used for the prophylaxis of acute rejection after renal transplantation. Few studies have described belatacept pharmacokinetics, and the effect of therapeutic drug monitoring has not been investigated. We
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