SRP5346

CyclinC, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonyme(s) : CCNC, CycC
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Produit recombinant: expressed in baculovirus infected Sf9 cells
• Pureté: ≥70% (SDS-PAGE)
• Forme: buffered aqueous glycerol solution
• Poids mol.: ~55 kDa
• Numéro d'accès NCBI: NM_005190
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... CCNC(892)

Description

Description générale

Cyclin C is a member of the cyclin family of proteins. The gene encoding it is localized on human chromosome 6q16.2.

Actions biochimiques/physiologiques

Cyclin C interacts with the cyclin-dependent kinase 8 (CDK8) and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human hematopoietic stem cells. Cyclin C can also associate with CDK3 to enhance retinoblastoma phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.

Forme physique

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Notes préparatoires

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable