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SRP5077

Sigma-Aldrich

PTPN7, active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

BPTP-4, HEPTP, LPTP, PTPNI

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Produit recombinant

expressed in E. coli

Essai

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Activité spécifique

1309-1771 nmol/min·mg

Poids mol.

~67 kDa

Numéro d'accès NCBI

NM_002832

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... PTPN7(5778)

Description générale

PTPN7 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN7 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.

Forme physique

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

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Certificats d'analyse (COA)

Lot/Batch Number
B024-1

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Consulter la Bibliothèque de documents

M Oh-hora et al.
Journal of immunology (Baltimore, Md. : 1950), 163(3), 1282-1288 (1999-07-22)
Leukocyte protein tyrosine phosphatase (LC-PTP)/hemopoietic PTP is a human cytoplasmic PTP that is predominantly expressed in the hemopoietic cells. Recently, it was reported that hemopoietic PTP inhibited TCR-mediated signal transduction. However, the precise mechanism of the inhibition was not identified.
S M Pettiford et al.
Oncogene, 19(7), 858-869 (2000-03-07)
HePTP is a tyrosine specific protein phosphatase that is strongly expressed in activated T-cells. It was recently demonstrated that in transfected T-cells HePTP impairs TCR-mediated activation of the MAP-kinase family members ERK2 and p38 and it was suggested that both
M Adachi et al.
Cancer research, 52(3), 737-740 (1992-02-01)
Protein-tyrosine phosphatase (PTP)-related complementary DNAs from NALM-6 (pre-B cell line) were amplified by reverse transcriptase polymerase chain reaction using primers corresponding to the conserved catalytic domains of PTPs. Thirty-three polymerase chain reaction products, identified as PTP related complementary DNAs, were

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